New York Giants vs. Washington Commanders early prediction: Expert picks for NFL Week 1, 2025

The New York Giants and Washington Commanders will meet in Week 1 of the NFL season at Northwest Stadium on Sunday, September 7, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the Commanders as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Giants vs. Commanders predictions page.

NY Giants vs. Washington early predictions

Leveraging trusted machine learning and analysis, we have simulated the Giants vs. Commanders game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Giants 26%, Commanders 74%
• Predicted final score: Giants 19-26 Commanders
• Spread: Giants (+6) 46%, Commanders (-6) 54%
• Total points (45.5): Over 53%, Under 47%

As of August 31, 2025, these Giants-Commanders calculations and predictions reflect the latest data and insights available.

Giants vs. Commanders Week 1 details

The NFL Week 1 matchup between the Commanders and Giants at Northwest Stadium is scheduled for September 7, 2025.

• Who: New York Giants vs. Washington Commanders
• Date: Sunday, September 7, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Northwest Stadium

Giants vs. Commanders opening odds

We've researched the best betting odds across America for this Week 1 game, which are listed here:

• Spread: Giants +6 (-110), Commanders -6 (-108)
• Moneyline: Giants +225, Commanders -260
• Total: Over/Under 45.5 (-112/-105)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Commanders, with a 74% win probability, will likely beat the Giants in Week 1 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Giants vs. Commanders game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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