New York Giants vs. New Orleans Saints early prediction: Expert picks for NFL Week 5, 2025

The New York Giants and New Orleans Saints will meet in Week 5 of the NFL season at Caesars Superdome on Sunday, October 5, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Giants as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Giants vs. Saints predictions page.

NY Giants vs. New Orleans early predictions

Leveraging trusted machine learning and analysis, we have simulated the Giants vs. Saints game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Giants 61%, Saints 39%
• Predicted final score: Giants 21-19 Saints
• Spread: Giants (-1.5) 53%, Saints (+1.5) 47%
• Total points (42.5): Over 46%, Under 54%

As of September 28, 2025, these Giants-Saints figures and predictions reflect the latest data and insights available.

Giants vs. Saints Week 5 details

The NFL Week 5 action between the Saints and Giants at Caesars Superdome is scheduled for October 5, 2025.

• Who: New York Giants vs. New Orleans Saints
• Date: Sunday, October 5, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Caesars Superdome

Giants vs. Saints opening odds

We've researched the best betting odds across America for this Week 5 game, which are listed here:

• Spread: Giants -1.5 (-110), Saints +1.5 (-110)
• Moneyline: Giants -125, Saints +105
• Total: Over/Under 42.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Giants, with a 61% win probability, will likely beat the Saints in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Giants vs. Saints game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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