New York Giants vs. Dallas Cowboys early prediction: Expert picks for NFL Week 2, 2025

The New York Giants and Dallas Cowboys will meet in Week 2 of the NFL season at AT&T Stadium on Sunday, September 14, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Cowboys as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Giants vs. Cowboys predictions page.

NY Giants vs. Dallas early predictions

Leveraging trusted machine learning and analysis, we have simulated the Giants vs. Cowboys game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Giants 36%, Cowboys 64%
• Predicted final score: Giants 20-23 Cowboys
• Spread: Giants (+4.5) 54%, Cowboys (-4.5) 46%
• Total points (44.5): Over 50%, Under 50%

As of September 7, 2025, these Giants-Cowboys figures and predictions reflect the latest data and insights available.

Giants vs. Cowboys Week 2 details

The NFL Week 2 game between the Cowboys and Giants at AT&T Stadium is scheduled for September 14, 2025.

• Who: New York Giants vs. Dallas Cowboys
• Date: Sunday, September 14, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: AT&T Stadium

Giants vs. Cowboys opening odds

We've researched the best betting odds across America for this Week 2 game, which are listed here:

• Spread: Giants +4.5 (-115), Cowboys -4.5 (-105)
• Moneyline: Giants +164, Cowboys -198
• Total: Over/Under 44.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Cowboys, with a 64% win probability, will likely beat the Giants in Week 2 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Giants vs. Cowboys matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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