New Orleans Saints vs. Seattle Seahawks early prediction: Expert picks for NFL Week 3, 2025

The New Orleans Saints and Seattle Seahawks will meet in Week 3 of the NFL season at Lumen Field on Sunday, September 21, 2025, starting at 4:05PM ET.

Initial simulations from Dimers' trusted NFL model favor the Seahawks as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Saints vs. Seahawks predictions page.

New Orleans vs. Seattle early predictions

Leveraging trusted machine learning and analysis, we have simulated the Saints vs. Seahawks game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Saints 27%, Seahawks 73%
• Predicted final score: Saints 18-24 Seahawks
• Spread: Saints (+6.5) 50%, Seahawks (-6.5) 50%
• Total points (43.5): Over 50%, Under 50%

As of September 14, 2025, these Saints-Seahawks numbers and predictions reflect the latest data and insights available.

Saints vs. Seahawks Week 3 details

The NFL Week 3 action between the Seahawks and Saints at Lumen Field is scheduled for September 21, 2025.

• Who: New Orleans Saints vs. Seattle Seahawks
• Date: Sunday, September 21, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Lumen Field

Saints vs. Seahawks opening odds

We've researched the best betting odds across America for this Week 3 game, which are listed here:

• Spread: Saints +6.5 (-105), Seahawks -6.5 (-115)
• Moneyline: Saints +230, Seahawks -285
• Total: Over/Under 43.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Seahawks, with a 73% win probability, will likely beat the Saints in Week 3 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Saints vs. Seahawks game, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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