New Orleans Saints vs. Buffalo Bills updated prediction featuring Alvin Kamara, James Cook [Week 4, 2025]

Dimers' latest NFL predictions are live for Buffalo Bills and New Orleans Saints in Week 4, with our model giving the Bills a 89% of winning against the Saints on Sunday.

This update builds on our early Bills-Saints predictions, providing refreshed win probabilities, score projections, and TD predictions for Alvin Kamara, James Cook, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Saints vs. Bills page.

What's changed? New Orleans vs. Buffalo updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Saints vs. Bills matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: Saints 11%, Bills 89%
• Predicted Final Score: Saints 17-31 Bills
• Spread: Saints (+15.5) 54%, Bills (-15.5) 46%
• Total Points (47.5): Over 53%, Under 47%

As of September 25, 2025, these Saints-Bills numbers reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New projections highlight the top candidates to find the end zone in Saints-Bills on Sunday:

New Orleans Saints

• Alvin Kamara: 41.7% probability
• Juwan Johnson: 25.9% probability
• Chris Olave: 25.3% probability

Buffalo Bills

• James Cook: 59.5% probability
• Josh Allen: 50.9% probability
• Keon Coleman: 33.1% probability

Saints vs. Bills latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Saints +15.5 (-110), Bills -15.5 (-108)
• Moneyline: Saints +1000, Bills -1400
• Total: Over/Under 47.5 (-115/-105)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Saints vs. Bills Week 4 details

The NFL Week 4 game between the Bills and Saints at Highmark Stadium is scheduled for September 28, 2025.

• Who: New Orleans Saints vs. Buffalo Bills
• Date: Sunday, September 28, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Highmark Stadium

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Conclusion

We predict the Bills, with an 89% win probability, will likely beat the Saints in Week 4 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Saints vs. Bills game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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