Naomi Osaka vs. Coco Gauff prediction, odds, picks for US Open 2025

Naomi Osaka will take on Coco Gauff in the fourth round of the US Open Women's Singles 2025 on Monday.

Based on the latest simulations, Dimers' advanced tennis model predicts Coco Gauff as the most likely winner of the match.

For a closer look at Monday's match, including best bets and picks, visit our interactive Osaka vs. Gauff predictions page.

Osaka vs. Gauff prediction: Who will win and advance to the Quarterfinals?

Using trusted machine learning and data analysis, we have simulated the result of Monday's Osaka-Gauff women's singles match 10,000 times as part of our tennis predictions coverage.

Our leading predictive model gives Gauff a 53% chance of beating Osaka in the US Open 2025.

Additionally, Gauff has a 52% chance of winning the first set, while the under 22.5 games has a 54% chance of hitting, according to our model.

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Naomi Osaka vs. Coco Gauff odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Osaka	Gauff
Moneyline	+116	-135
First Set	+110	-139
Total Games	o22.5 (+100)	u22.5 (-130)

All odds are correct at the time of publication and are subject to change.

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Osaka vs. Gauff picks and best bets

Our model's biggest edge in today's Osaka vs. Gauff match is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best tennis picks and tennis best bets for every tournament throughout the year.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Osaka vs. Gauff updates and essential details

The US Open 2025 match between Naomi Osaka and Coco Gauff is scheduled to begin on Monday at 2:05PM ET.

• Who: Naomi Osaka vs. Coco Gauff
• Date: Monday, September 1, 2025
• Approx. Time: 2:05PM ET/11:05AM PT
• Tournament: US Open Women's Singles 2025
• Round: Fourth round

All dates and times mentioned in this article are United States Eastern Time unless otherwise stated.

Dimers.com's full preview of Monday's Osaka vs. Gauff match includes our prediction, picks and the latest betting odds.

Before making any Naomi Osaka vs. Coco Gauff picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key tennis betting guides and insights

• Learn how to bet on tennis and understand how tennis odds work
• Explore where sports odds come from and how they’re applied to tennis matches
• Stay informed with guides on where online sports betting is currently legal and which states could legalize next
• Improve your chances with proven sports betting strategies that apply to tennis and more

Conclusion

We predict Coco Gauff, with a 53% win probability, will likely beat Naomi Osaka at the US Open 2025.

AI and automation have enhanced this article to quickly deliver accurate Osaka vs. Gauff insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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