Murray State vs. Jacksonville State prediction: Jacksonville State favored to win in college football Week 4, 2025

Jacksonville State will face Murray State in Week 4 college football action at AmFirst Stadium on Saturday, commencing at 7:00PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Jacksonville State as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Murray State vs. Jacksonville State predictions page.

Murray State vs. Jacksonville State prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Murray State vs. Jacksonville State 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Jacksonville State a 98% chance of defeating Murray State. Our predicted final score has Jacksonville State winning 47-11.

According to our model, the bookmakers have got it right, and Murray State and Jacksonville State each have a 50% chance of covering the spread, while the over/under total of 60.5 points has a 57% chance of going over.

Murray State vs. Jacksonville State odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Murray State	Jacksonville State
Spread	+35.5 (+100)	-35.5 (-110)
Moneyline	+5500	-50000
Total	o60.5 (-110)	u60.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Murray State vs. Jacksonville State picks and best bets

Our model's strongest edge in today's Murray State vs. Jacksonville State matchup is on the spread.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Murray State vs. Jacksonville State game-day updates and essential details

Saturday's college football game between Jacksonville State and Murray State at AmFirst Stadium is scheduled to start at 7:00PM ET.

• Who: Murray State vs. Jacksonville State
• Date: Saturday, September 20, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: AmFirst Stadium

Dimers' comprehensive preview of Saturday's Murray State vs. Jacksonville State matchup includes our prediction, picks and the latest betting odds.

Before making any Murray State vs. Jacksonville State picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Jacksonville State, with a 98% win probability, will likely beat Murray State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Murray State vs. Jacksonville State insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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