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Monterrey vs. Santos Laguna prediction, odds, Liga MX picks [9/27/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Monterrey vs Santos Laguna predictions for Liga MX Saturday.
Monterrey will take on Santos Laguna in Liga MX action on Saturday, commencing at 9:00PM ET.
Based on the latest simulations, Dimers' advanced Liga MX model projects Monterrey as the most likely winner of today's game.
For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Monterrey vs. Santos Laguna predictions page.
Monterrey vs. Santos Laguna prediction: Who will win?
Using powerful machine learning and data analysis, we have simulated the outcome of Saturday's Liga MX matchup between Monterrey and Santos Laguna 10,000 times as part of our Liga MX predictions coverage.
Our leading predictive model indicates a 75.6% chance of Monterrey winning, a 9.3% chance for Santos Laguna, and a 15.1% chance of a draw.
Monterrey vs. Santos Laguna odds
We have researched the best Liga MX odds in America for this game, which are listed here:
| Market | Monterrey | Santos Laguna | Draw |
|---|---|---|---|
| Moneyline | -350 | +775 | +500 |
All odds are correct at the time of publication and are subject to change.
Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.
Monterrey vs. Santos Laguna picks and best bets
Our model's strongest edge in today's Monterrey vs. Santos Laguna matchup is on the moneyline.
Our expert predictions, aligned with the current odds, reveal the best Liga MX picks and Liga MX best bets for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
Monterrey vs. Santos Laguna: Correct score and BTTS predictions
Here are the top three most likely final scores according to our model, with a 2-0 Monterrey win being the most probable:
| Final Score | Probability |
|---|---|
| MNT 2-0 SLA | 11.5% |
| MNT 3-0 SLA | 9.8% |
| MNT 2-1 SLA | 9.1% |
When it comes to the both teams to score (BTTS) market, we project a 50.3% chance that both teams scoring, and a 49.7% probability of at least one team keeping a clean sheet.
These predictions are based on each team's average score after 10,000 simulations.
Monterrey vs. Santos Laguna game-day updates and essential details
Saturday's matchup between Monterrey and Santos Laguna is scheduled to commence at 9:00PM ET.
- Who: Monterrey vs. Santos Laguna
- Date: Saturday, September 27, 2025
- Time: 9:00PM ET/6:00PM PT
Dimers' full preview of Saturday's Monterrey vs. Santos Laguna matchup includes our prediction, picks and the latest betting odds.
Before making any Santos Laguna vs. Monterrey picks, be sure to check out the latest Liga MX predictions and betting advice from Dimers Pro.
Conclusion
According to our computer model, Monterrey has a 75.6% win probability on Saturday, Santos Laguna has a 9.3% win probability, and there is a 15.1% chance that the game will end in a draw.
AI and automation have enhanced this article to quickly deliver accurate Monterrey vs. Santos Laguna insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on Liga MX
Keep up with the latest Liga MX betting news and parlay picks throughout the season.
Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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