MLS betting tips: Sunday's picks include Seattle vs. Austin play [9/21/2025]

Today’s MLS betting tips for September 21, 2025 are here, with Sunday’s MLS best bets fueled by thousands of data simulations analyzing the latest odds and matchups.

These MLS best bets include matchups like the Seattle vs. Austin game at 7:00PM ET, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

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Pro members get unlimited access to everything Dimers has to offer on Sunday, September 21, 2025, including our full suite of picks and best bets for today and the week ahead.

List of MLS betting tips tonight [9/21, updated 6:31PM ET]

After diving deep into the numbers and running thousands of simulations, our famous predictive analytics model has figured out the best soccer bet for Sunday, September 21, 2025.

Austin ML (+200)

• Probability: 35.8%
• Edge: 2.5%
• Matchup: Seattle vs. Austin (7:00PM ET, Sunday)

Our model has pinpointed a high-probability MLS betting opportunity tonight, which comes in the Seattle vs. Austin game. We recommend a bet on Austin ML at +200 odds, with our analysis showing a 35.8% chance of hitting and a compelling edge of 2.5%.

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List of upcoming MLS games to bet on [9/21/2025]

• Seattle vs. Austin (7:00PM ET, Sunday)
• Salt Lake vs. LAFC (9:00PM ET, Sunday)

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More on MLS

The bets on this page form part of our MLS best bets series.

For more MLS betting content, we have MLS betting news and the latest MLS Cup odds and predictions.

Conclusion

Our MLS best bets are locked and loaded for September 21, 2025, featuring plays such as Austin ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLS insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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