MLB Home Run Predictions for Wednesday Highlight Kyle Schwarber [5/21/2025]

As Wednesday’s MLB action gets underway on May 21, Kyle Schwarber leads the list of players most likely to hit a home run, according to the latest Dimers Pro simulation data.

With thousands of fans placing bets on home run props daily, our team has simulated every MLB game on the Wednesday slate 10,000 times. The table below highlights the players with the highest probabilities of hitting a home run in today’s games, all sourced from Wednesday's MLB hitter projections.

Who’s Most Likely to Hit a Home Run Today? [MLB Cheat Sheet for May 21, 2025]

According to our projections, Schwarber tops today’s list with a 29.5% chance to hit a home run against the Rockies. Right behind him are Brent Rooker (26.0%) and Shea Langeliers (25.5%), both strong options in the Athletics’ matchup against the Angels.

Dimers Pro Pick of the Day: MLB HR Prop [Wednesday, 5/21/2025]

After evaluating player projections, weather factors, and pitching matchups, our model has surfaced one standout home run value bet for Wednesday.

For more MLB picks, including full access to our complete HR prop board and today's pitcher props, join Dimers Pro.

Shea Langeliers To Hit a Home Run

• Odds: +425
• Edge: 4.8%
• Probability: 25.5%
• Game: Athletics vs. Angels (10:05PM ET)

Ranked as one of the top three most likely players to hit a home run today, Shea Langeliers offers a strong +425 payout with Bet365, with an edge of 4.8% according to our projections. This combination of above-market value and power potential makes Langeliers the best HR bet on Wednesday’s slate.

Why MLB Home Run Props Are Popular with Bettors

Home run props offer compelling value and excitement, especially when backed by simulation-driven MLB predictions. While betting on a longball is never a sure thing, understanding probabilities and betting edges can lead to smarter wagers over time.

For a deeper look, sign up for Dimers Pro today. You’ll also gain access to hit projections, pitcher props, and more home run predictions—perfect for building your MLB round robins today.

MLB Schedule for Today [Wednesday, May 21, 2025]

• Reds @ Pirates — 12:35PM ET
• Guardians @ Twins — 1:10PM ET
• Astros @ Rays — 1:10PM ET
• Orioles @ Brewers — 1:10PM ET
• Cubs @ Marlins — 1:10PM ET
• Tigers @ Cardinals — 1:15PM ET
• Mariners @ White Sox — 2:10PM ET
• Royals @ Giants — 3:45PM ET
• Mets @ Red Sox — 6:45PM ET
• Braves @ Nationals — 6:45PM ET
• Rangers @ Yankees — 7:05PM ET
• Padres @ Blue Jays — 7:07PM ET
• Phillies @ Rockies — 8:40PM ET
• Angels @ Athletics — 10:05PM ET
• Diamondbacks @ Dodgers — 10:10PM ET

Conclusion

For May 21, 2025, our MLB home run predictions are locked in, with players like Kyle Schwarber, Brent Rooker, and Shea Langeliers projected to be among the most powerful bats in today’s games. Langeliers in particular stands out as the best value bet, offering a 4.8% edge at +425 odds with Bet365.

These insights are based on 10,000 game simulations and are designed to help you identify smarter betting opportunities. As always, gamble responsibly. If you or someone you know needs support, call 1-800-GAMBLER.

This article is part of our MLB player props and MLB best bets series. For more coverage, stay updated with the latest MLB news, MLB betting trends and World Series odds.

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