...
...
Read Article
Home run predictions for Monday include Fernando Tatis, Marcell Ozuna [9/22/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get home run predictions today driven by expert analysis of Monday's MLB slate.
Our MLB home run predictions for Monday, September 22, 2025, are here—with Fernando Tatis leading the list based on the latest Dimers Pro simulation data.
Monday's HR projections pull from our proprietary home run predictions, built to highlight the top slugging candidates today.
Home run predictions for September 22, 2025
| Player (Team) | HR Projection |
|---|---|
| Fernando Tatis (Padres) | 17.5% |
| Matt Olson (Braves) | 17.1% |
| Manny Machado (Padres) | 16.2% |
| Ronald Acuna (Braves) | 🔒 |
| Marcell Ozuna (Braves) | 🔒 |
| Rafael Devers (Giants) | 🔒 |
| Ramon Laureano (Padres) | 🔒 |
| Danny Jansen (Brewers) | 🔒 |
| Nolan Gorman (Cardinals) | 🔒 |
| Michael Harris (Braves) | 🔒 |
Our analysis shows Tatis leads today's MLB home run predictions with a 17.5% chance to go yard, followed by Matt Olson (17.1%) and Manny Machado (16.2%).
Ronald Acuna and Marcell Ozuna are among several other sluggers to crack the top 10. Want the full list of home run props today—including every player's HR prediction for Monday? Join Dimers Pro now.
Already a Dimers Pro member? Check out today's HR and hitter projections and sort by “To Hit HR” to see every player’s probability of going deep.
Monday's home run picks [9/22/2025]
After running 10,000 simulations per matchup and evaluating key factors like weather and pitching matchups, Dimers Pro has identified one of the best MLB home run props today.
Ryan O'Hearn (Padres) to hit a home run
- Probability: 12.2%
- Odds: +920
- Edge: 2.4%
- Game: Brewers vs. Padres (9:40PM ET)
- Pitching matchup: Freddy Peralta
Despite not cracking the top 10 in today's home run predictions, San Diego slugger Ryan O'Hearn offers serious value at +920 with DraftKings Sportsbook, showing an edge of 2.4%—making him one of the strongest home run bets today.
With Freddy Peralta on the mound for the Brewers, this combination of betting value and power potential makes O'Hearn one of the best home run picks today on Monday's slate.
For more expert MLB picks and data-backed MLB predictions, join Dimers Pro now. Pro users get full access to a total of 24 home run predictions today, plus hit and RBI projections, pitcher props, and more—perfect for building smarter MLB parlays and round robins.
MLB schedule for today [Monday, September 22, 2025]
- Nationals vs. Braves (7:15PM ET, Monday)
- Brewers vs. Padres (9:40PM ET, Monday)
- Cardinals vs. Giants (9:45PM ET, Monday)
Conclusion
For September 22, 2025, our MLB home run predictions are locked in, with sluggers like Fernando Tatis, Matt Olson and Manny Machado projected to be among the most powerful bats in today’s games. But it's Ryan O'Hearn who stands out as the best value bet, offering a favorable 2.4% edge at +920 odds.
These insights are based on 10,000 game simulations and are designed to help you identify smarter betting opportunities. As always, gamble responsibly. If you or someone you know needs support, call 1-800-GAMBLER.
For more coverage, check out today's MLB player props and MLB best bets. Plus, stay updated with the latest MLB news, MLB betting trends updated every 15 minutes, and World Series odds.
Note: This article may include affiliate links. Learn how we review products and services.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
Advertiser disclosure