Free MLB picks today: Wednesday's MLB best bets include Marlins vs. Rockies play [9/17/2025]

Today’s free MLB picks for September 17, 2025 are here, with Wednesday’s MLB best bets fueled by thousands of predictive simulations analyzing the latest odds and matchups.

These MLB best bets include matchups like the Marlins vs. Rockies game at 8:40PM ET, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Wednesday, September 17, 2025, including our full suite of picks and best bets for today and the week ahead.

List of MLB best bets tonight [9/17, updated 8:32PM ET]

After digging deep into the numbers and conducting thousands of simulations, our independent predictive analytics model has figured out the best baseball bets for Wednesday, September 17, 2025.

Rockies +1.5 (-115)

• Probability: 57.5%
• Edge: 4.0%
• Matchup: Marlins vs. Rockies (8:40PM ET, Wednesday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Marlins vs. Rockies matchup. We recommend a run line bet on Rockies +1.5 at -115 odds, with our analysis showing a 57.5% chance of hitting and a compelling edge of 4.0%.

Rockies ML (+130)

• Probability: 46.1%
• Edge: 3.1%
• Matchup: Marlins vs. Rockies (8:40PM ET, Wednesday)

Our model has found another strong MLB bet for Wednesday's baseball action, again in the game between the Marlins and Rockies. We suggest placing a wager on Rockies ML at +130 odds, with a 46.1% probability delivering a 3.1% edge.

MLB best bets: Wednesday, 9/17/2025

As of 8:32PM ET, here are our top two MLB bets by probability recommended by our model:

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's MLB picks is a +106 run line bet with a 4.5% edge—the kind of high-upside play that makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 17, 2025.

List of upcoming MLB games to bet on [9/17/2025]

• Marlins vs. Rockies (8:40PM ET, Wednesday)
• Phillies vs. Dodgers (10:10PM ET, Wednesday)
• Blue Jays vs. Rays (1:10PM ET, Thursday)
• Guardians vs. Tigers (1:10PM ET, Thursday)
• Padres vs. Mets (1:10PM ET, Thursday)
• Athletics vs. Red Sox (1:35PM ET, Thursday)
• Mariners vs. Royals (2:10PM ET, Thursday)
• Marlins vs. Rockies (3:10PM ET, Thursday)
• Yankees vs. Orioles (7:15PM ET, Thursday)
• Angels vs. Brewers (7:40PM ET, Thursday)

More on MLB

The bets on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for September 17, 2025, featuring plays such as Rockies +1.5 and Rockies ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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