Free MLB Picks Today: Saturday's MLB Best Bets Include Guardians vs. Athletics Play [6/21/2025]

Another action-packed MLB slate is on deck for 6/21, and our breakdown includes all the free MLB picks for today and the MLB best bets today worth riding.

Today's MLB best bets include matchups like Guardians vs. Athletics and Nationals vs. Dodgers, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Saturday, June 21, 2025, including our complete suite of MLB picks and best bets.

List of MLB Best Bets Tonight [6/21, Updated 10:01PM ET]

After crunching the numbers and running thousands of simulations, our leading predictive analytics model has figured out the best baseball bets for Saturday, June 21, 2025.

While these free MLB picks for today are sorted by probability, the real edge—the bets with the highest long-term value—is reserved for Dimers Pro subscribers. Because smart betting isn't just about what's likely—it's about what's profitable.

Athletics +1.5 (-142)

• Probability: 61.6%
• Edge: 2.9%
• Matchup: Guardians vs. Athletics (10:05PM ET, Saturday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Guardians vs. Athletics game. We recommend a run line bet on Athletics +1.5 at -142 odds, with our analysis showing a 61.6% chance of hitting and a compelling edge of 2.9%.

Nationals vs. Dodgers Under 10 Runs (-112)

• Probability: 55.7%
• Edge: 2.9%
• Matchup: Nationals vs. Dodgers (10:10PM ET, Saturday)

Our model has found another strong MLB bet for Saturday's baseball action, this time in the matchup between the Nationals and Dodgers. We suggest placing an over/under wager on Under 10 Runs at -112 odds, with a 55.7% probability delivering a 2.9% edge.

MORE: MLB Props

MLB Best Bets: Saturday, 6/21/2025

As of 10:01PM ET, here are our top two MLB bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Guardians vs. Athletics	Athletics +1.5	-142 @ FanDuel	61.6%	2.9%
Nationals vs. Dodgers	Under 10 Runs	-112 @ DraftKings	55.7%	2.9%

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Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to 10 MLB picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for June 21, 2025.

List of Upcoming MLB Games to Bet On [6/21/2025]

• Guardians vs. Athletics (10:05PM ET, Saturday)
• Nationals vs. Dodgers (10:10PM ET, Saturday)
• Orioles vs. Yankees (11:35AM ET, Sunday)
• Tigers vs. Rays (12:10PM ET, Sunday)
• Rangers vs. Pirates (1:35PM ET, Sunday)
• White Sox vs. Blue Jays (1:37PM ET, Sunday)
• Braves vs. Marlins (1:40PM ET, Sunday)
• Brewers vs. Twins (2:10PM ET, Sunday)
• Reds vs. Cardinals (2:15PM ET, Sunday)
• Mariners vs. Cubs (2:20PM ET, Sunday)
• D-Backs vs. Rockies (3:10PM ET, Sunday)
• Red Sox vs. Giants (4:05PM ET, Sunday)
• Guardians vs. Athletics (4:05PM ET, Sunday)
• Astros vs. Angels (4:07PM ET, Sunday)
• Nationals vs. Dodgers (4:10PM ET, Sunday)
• Royals vs. Padres (4:10PM ET, Sunday)
• Mets vs. Phillies (7:10PM ET, Sunday)

More About MLB

The best on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for June 21, 2025, featuring plays such as Athletics +1.5 and Under 10 Runs in the Nationals vs. Dodgers matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.