Free MLB Picks Today: Wednesday's MLB Best Bets Include Two Run Line Plays [5/28/2025]

Another action-packed MLB slate is on deck for 5/28, and we've locked in our free MLB picks for today and MLB best bets today to help you cash in on Wednesday's action.

Today's MLB best bets include matchups like Nationals vs. Mariners and Yankees vs. Angels, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Wednesday, May 28, 2025, including our full set of MLB picks and best bets.

List of MLB Best Bets Tonight [5/28, Updated 9:33PM ET]

After crunching the numbers and conducting thousands of simulations, our famous predictive analytics model has identified the best baseball bets for Wednesday, May 28, 2025.

While these free MLB picks for today are sorted by probability, the real edge—the bets with the highest long-term value—is reserved for Dimers Pro subscribers. Because smart betting isn't just about what's likely—it's about what's profitable.

Nationals +1.5 (-115)

• Probability: 57.2%
• Edge: 3.7%
• Matchup: Nationals vs. Mariners (9:40PM ET, Wednesday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Nationals vs. Mariners game. We recommend a run line bet on Nationals +1.5 at -115 odds, with our analysis showing a 57.2% chance of hitting and a compelling edge of 3.7%.

Angels +1.5 (-118)

• Probability: 56.7%
• Edge: 2.6%
• Matchup: Yankees vs. Angels (9:38PM ET, Wednesday)

Our model has found another strong MLB bet for Wednesday's baseball action, this time in the game between the Yankees and Angels. We suggest placing a run line wager on Angels +1.5 at -118 odds, with a 56.7% probability delivering a 2.6% edge.

MORE: MLB Props

Angels ML (+140)

• Probability: 44.4%
• Edge: 2.8%
• Matchup: Yankees vs. Angels (9:38PM ET, Wednesday)

Our model has found another strong MLB bet for Wednesday's baseball action, also in the Yankees vs. Angels matchup. We recommend a bet on Angels ML at +140 odds. Our model shows a 44.4% probability and 2.8% edge for this wager.

MORE: Wednesday's MLB Trends

MLB Best Bets: Wednesday, 5/28/2025

As of 9:33PM ET, here are our top three MLB bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Nationals vs. Mariners	Nationals +1.5	-115 @ DraftKings	57.2%	3.7%
Yankees vs. Angels	Angels +1.5	-118 @ BetMGM	56.7%	2.6%
Yankees vs. Angels	Angels ML	+140 @ DraftKings	44.4%	2.8%

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Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to five MLB picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for May 28, 2025.

List of Upcoming MLB Games to Bet On [5/28/2025]

• Yankees vs. Angels (9:38PM ET, Wednesday)
• Nationals vs. Mariners (9:40PM ET, Wednesday)
• Braves vs. Phillies (6:45PM ET, Thursday)
• Athletics vs. Blue Jays (7:07PM ET, Thursday)
• Rays vs. Astros (8:10PM ET, Thursday)

More on MLB

The best on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for May 28, 2025, featuring plays such as Nationals +1.5 and Angels +1.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.