Free MLB picks today: Thursday's MLB best bets include Rockies vs. Mariners play [9/25/2025]

Today’s free MLB picks for September 25, 2025 are here, with Thursday’s MLB best bets powered by thousands of data simulations analyzing the latest odds and matchups.

These MLB best bets include matchups like the Rockies vs. Mariners game at 9:40PM ET, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Thursday, September 25, 2025, including our full set of picks and best bets for today and the week ahead.

List of MLB best bets tonight [9/25, updated 9:34PM ET]

After diving deep into the numbers and conducting thousands of simulations, our famous predictive analytics model has identified the best baseball bet for Thursday, September 25, 2025.

Rockies vs. Mariners over 7.5 runs (-120)

• Probability: 61.9%
• Edge: 7.3%
• Matchup: Rockies vs. Mariners (9:40PM ET, Thursday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Rockies vs. Mariners game. We recommend an over/under bet on over 7.5 runs at -120 odds, with our analysis showing a 61.9% chance of hitting and a compelling edge of 7.3%.

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Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 25, 2025.

List of upcoming MLB games to bet on [9/25/2025]

• Royals vs. Angels (9:38PM ET, Thursday)
• Rockies vs. Mariners (9:40PM ET, Thursday)
• Twins vs. Phillies (6:45PM ET, Friday)
• White Sox vs. Nationals (6:45PM ET, Friday)
• Orioles vs. Yankees (7:05PM ET, Friday)
• Rays vs. Blue Jays (7:07PM ET, Friday)
• Mets vs. Marlins (7:10PM ET, Friday)
• Rangers vs. Guardians (7:10PM ET, Friday)
• Pirates vs. Braves (7:15PM ET, Friday)
• Reds vs. Brewers (8:10PM ET, Friday)

More about MLB

The bets on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for September 25, 2025, featuring plays such as over 7.5 runs in the Rockies vs. Mariners matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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