Free MLB picks today: Monday's MLB best bets include two over/under plays [9/22/2025]

Today’s free MLB picks for September 22, 2025 are here, with Monday’s MLB best bets built on tens of thousands of predictive simulations analyzing the latest odds and matchups.

These MLB best bets include matchups like Cardinals vs. Giants and Brewers vs. Padres, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Monday, September 22, 2025, including our complete suite of picks and best bets for today and the week ahead.

List of MLB best bets tonight [9/22, updated 9:33PM ET]

After crunching the numbers and conducting thousands of simulations, our independent predictive analytics model has figured out the best baseball bets for Monday, September 22, 2025.

Cardinals vs. Giants over 7.5 runs (-115)

• Probability: 57.1%
• Edge: 3.6%
• Matchup: Cardinals vs. Giants (9:45PM ET, Monday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Cardinals vs. Giants matchup. We recommend an over/under bet on over 7.5 runs at -115 odds, with our analysis showing a 57.1% chance of hitting and a compelling edge of 3.6%.

Brewers vs. Padres over 7 runs (-102)

• Probability: 57%
• Edge: 6.5%
• Matchup: Brewers vs. Padres (9:40PM ET, Monday)

Our model has found another strong MLB bet for Monday's baseball action, this time in the game between the Brewers and Padres. We suggest placing an over/under wager on over 7 runs at -102 odds, with a 57% probability delivering a 6.5% edge.

MLB best bets: Monday, 9/22/2025

As of 9:33PM ET, here are our top two MLB bets by probability recommended by our model:

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's MLB picks is a -104 over/under bet with a 7.3% edge—the kind of high-upside play that makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 22, 2025.

List of upcoming MLB games to bet on [9/22/2025]

• Brewers vs. Padres (9:40PM ET, Monday)
• Cardinals vs. Giants (9:45PM ET, Monday)
• Rays vs. Orioles (6:35PM ET, Tuesday)
• Tigers vs. Guardians (6:40PM ET, Tuesday)
• Pirates vs. Reds (6:40PM ET, Tuesday)
• Marlins vs. Phillies (6:45PM ET, Tuesday)
• White Sox vs. Yankees (7:05PM ET, Tuesday)
• Red Sox vs. Blue Jays (7:07PM ET, Tuesday)
• Nationals vs. Braves (7:15PM ET, Tuesday)
• Mets vs. Cubs (7:40PM ET, Tuesday)

More about MLB

The bets on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for September 22, 2025, featuring plays such as over 7.5 runs in the Cardinals vs. Giants matchup and over 7 runs in the Brewers vs. Padres matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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