Free MLB picks today: Friday's MLB best bets include two over/under plays [9/26/2025]

Today’s free MLB picks for September 26, 2025 are here, with Friday’s MLB best bets fueled by tens of thousands of data simulations analyzing the latest odds and matchups.

These MLB best bets include matchups like Royals vs. Athletics and Rockies vs. Giants, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Friday, September 26, 2025, including our full set of picks and best bets for today and the week ahead.

List of MLB best bets tonight [9/26, updated 10:01PM ET]

After crunching the numbers and running thousands of simulations, our leading predictive analytics model has figured out the best baseball bets for Friday, September 26, 2025.

Royals vs. Athletics over 10 runs (-120)

• Probability: 57.1%
• Edge: 2.6%
• Matchup: Royals vs. Athletics (10:05PM ET, Friday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Royals vs. Athletics matchup. We recommend an over/under bet on over 10 runs at -120 odds, with our analysis showing a 57.1% chance of hitting and a compelling edge of 2.6%.

Rockies vs. Giants over 8.5 runs (-105)

• Probability: 55.5%
• Edge: 4.3%
• Matchup: Rockies vs. Giants (10:15PM ET, Friday)

Our model has found another strong MLB bet for Friday's baseball action, this time in the game between the Rockies and Giants. We suggest placing an over/under wager on over 8.5 runs at -105 odds, with a 55.5% probability delivering a 4.3% edge.

MLB best bets: Friday, 9/26/2025

As of 10:01PM ET, here are our top two MLB bets by probability recommended by our model:

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to 13 MLB picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 26, 2025.

List of upcoming MLB games to bet on [9/26/2025]

• Royals vs. Athletics (10:05PM ET, Friday)
• Rockies vs. Giants (10:15PM ET, Friday)
• Orioles vs. Yankees (1:05PM ET, Saturday)
• Cardinals vs. Cubs (2:20PM ET, Saturday)
• Rays vs. Blue Jays (3:07PM ET, Saturday)
• White Sox vs. Nationals (4:05PM ET, Saturday)
• Rockies vs. Giants (4:05PM ET, Saturday)
• Mets vs. Marlins (4:10PM ET, Saturday)
• Twins vs. Phillies (6:05PM ET, Saturday)
• Pirates vs. Braves (7:15PM ET, Saturday)
• D-Backs vs. Padres (8:40PM ET, Saturday)

More on MLB

The bets on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for September 26, 2025, featuring plays such as over 10 runs in the Royals vs. Athletics matchup and over 8.5 runs in the Rockies vs. Giants matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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