Free MLB picks today: Friday's MLB best bets include Phillies vs. Diamondbacks play [9/19/2025]

Today’s free MLB picks for September 19, 2025 are here, with Friday’s MLB best bets powered by tens of thousands of predictive simulations analyzing the latest odds and matchups.

These MLB best bets include matchups like the Phillies vs. Diamondbacks game at 9:40PM ET, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Friday, September 19, 2025, including our complete suite of picks and best bets for today and the week ahead.

List of MLB best bets tonight [9/19, updated 9:31PM ET]

After crunching the numbers and running thousands of simulations, our independent predictive analytics model has identified the best baseball bet for Friday, September 19, 2025.

Phillies vs. Diamondbacks over 9 runs (-120)

• Probability: 57.4%
• Edge: 2.9%
• Matchup: Phillies vs. Diamondbacks (9:40PM ET, Friday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Phillies vs. Diamondbacks game. We recommend an over/under bet on over 9 runs at -120 odds, with our analysis showing a 57.4% chance of hitting and a compelling edge of 2.9%.

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's MLB picks is a -110 over/under bet with a 4.5% edge—the kind of high-upside play that makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 19, 2025.

List of upcoming MLB games to bet on [9/19/2025]

• Phillies vs. D-Backs (9:40PM ET, Friday)
• Giants vs. Dodgers (10:10PM ET, Friday)
• Braves vs. Tigers (1:10PM ET, Saturday)
• Nationals vs. Mets (4:10PM ET, Saturday)
• Cubs vs. Reds (6:40PM ET, Saturday)
• Athletics vs. Pirates (6:40PM ET, Saturday)
• Red Sox vs. Rays (7:05PM ET, Saturday)
• Yankees vs. Orioles (7:05PM ET, Saturday)
• Marlins vs. Rangers (7:05PM ET, Saturday)
• Blue Jays vs. Royals (7:10PM ET, Saturday)
• Mariners vs. Astros (7:10PM ET, Saturday)
• Padres vs. White Sox (7:10PM ET, Saturday)
• Brewers vs. Cardinals (7:15PM ET, Saturday)
• Angels vs. Rockies (8:10PM ET, Saturday)
• Phillies vs. D-Backs (8:10PM ET, Saturday)
• Giants vs. Dodgers (9:10PM ET, Saturday)

More about MLB

The bets on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for September 19, 2025, featuring plays such as over 9 runs in the Phillies vs. Diamondbacks matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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