Free MLB picks today: Thursday's MLB best bets revealed after 10,000 simulations [8/21/2025]

Today’s free MLB picks for August 21, 2025 are here, with Thursday’s MLB best bets powered by thousands of predictive simulations analyzing the latest odds and matchups.

Today's MLB best bets will be sourced from matchups such as Astros vs. Orioles, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

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List of MLB best bets today [8/21, updated 7:02PM ET]

Having simulated today's remaining MLB action 10,000 times, our model has determined there are no MLB bets worth making right now. This is because there are currently no favorable edges between our data-driven probabilities and the best available odds.

List of Upcoming MLB Games to Bet On [8/21/2025]

• Astros vs. Orioles (7:15PM ET, Thursday)
• Red Sox vs. Yankees (7:15PM ET, Thursday)
• Cardinals vs. Rays (7:35PM ET, Thursday)
• Rockies vs. Pirates (6:40PM ET, Friday)
• Nationals vs. Phillies (6:45PM ET, Friday)

More on MLB

The best on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for August 21, 2025, with our in-house predictive analytics model constantly searching for bets across Thursday's action.. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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