Free MLB picks today: Saturday's MLB best bets include two over/under plays [9/6/2025]

Today’s free MLB picks for September 6, 2025 are here, with Saturday’s MLB best bets driven by tens of thousands of predictive simulations analyzing the latest odds and matchups.

These MLB best bets include matchups like Astros vs. Rangers and Dodgers vs. Orioles, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Saturday, September 6, 2025, including our complete set of picks and best bets for today and the week ahead.

List of MLB best bets tonight [9/6, updated 3:01PM ET]

After crunching the numbers and conducting thousands of simulations, our independent predictive analytics model has figured out the best baseball bets for Saturday, September 6, 2025.

Astros vs. Rangers over 7 runs (-102)

• Probability: 55.8%
• Edge: 5.3%
• Matchup: Astros vs. Rangers (7:15PM ET, Saturday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Astros vs. Rangers matchup. We recommend an over/under bet on over 7 runs at -102 odds, with our analysis showing a 55.8% chance of hitting and a compelling edge of 5.3%.

Dodgers vs. Orioles over 7.5 runs (-114)

• Probability: 55.3%
• Edge: 2.0%
• Matchup: Dodgers vs. Orioles (7:05PM ET, Saturday)

Our model has found another strong MLB bet for Saturday's baseball action, this time in the game between the Dodgers and Orioles. We suggest placing an over/under wager on over 7.5 runs at -114 odds, with a 55.3% probability delivering a 2.0% edge.

Rockies +1.5 (+115)

• Probability: 49.4%
• Edge: 2.9%
• Matchup: Padres vs. Rockies (8:10PM ET, Saturday)

Our model has found another strong MLB bet for today's baseball action,this time in the Padres vs. Rockies matchup. We recommend a run line bet on Rockies +1.5 at +115 odds. Our model shows a 49.4% probability and 2.9% edge for this wager.

MLB best bets: Saturday, 9/6/2025

As of 3:01PM ET, here are our top three MLB bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Astros vs. Rangers	Over 7 Runs	-102 @ BetMGM	55.8%	5.3%
Dodgers vs. Orioles	Over 7.5 Runs	-114 @ FanDuel	55.3%	2.0%
Padres vs. Rockies	Rockies +1.5	+115 @ FanDuel	49.4%	2.9%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to four MLB picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 6, 2025.

List of upcoming MLB games to bet on [9/6/2025]

• Phillies vs. Marlins (4:10PM ET, Saturday)
• White Sox vs. Tigers (6:10PM ET, Saturday)
• Mets vs. Reds (6:40PM ET, Saturday)
• Brewers vs. Pirates (6:40PM ET, Saturday)
• Dodgers vs. Orioles (7:05PM ET, Saturday)
• Guardians vs. Rays (7:05PM ET, Saturday)
• Twins vs. Royals (7:15PM ET, Saturday)
• Mariners vs. Braves (7:15PM ET, Saturday)
• Astros vs. Rangers (7:15PM ET, Saturday)
• Red Sox vs. D-Backs (8:10PM ET, Saturday)
• Padres vs. Rockies (8:10PM ET, Saturday)
• Athletics vs. Angels (9:38PM ET, Saturday)
• Mariners vs. Braves (12:05PM ET, Sunday)
• Guardians vs. Rays (12:10PM ET, Sunday)
• Dodgers vs. Orioles (1:35PM ET, Sunday)
• Blue Jays vs. Yankees (1:35PM ET, Sunday)
• Mets vs. Reds (1:40PM ET, Sunday)
• White Sox vs. Tigers (1:40PM ET, Sunday)
• Twins vs. Royals (2:10PM ET, Sunday)
• Astros vs. Rangers (2:35PM ET, Sunday)

Bet365 bonus code "DIMERS" — perfect for MLB Saturday betting

To make the most of Saturday's MLB best bets, including the Astros vs. Rangers matchup, check out the new Bet365 bonus code "DIMERS" that grants you $300 in bonus bets from a $5 bet – win or lose. Don't miss out!

More on MLB

The best on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for September 6, 2025, featuring plays such as over 7 runs in the Astros vs. Rangers matchup and over 7.5 runs in the Dodgers vs. Orioles matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

Note: Clicking links to our sportsbook partners may earn us a referral fee. Learn about how we review products and services.