Free MLB picks today: Friday's MLB best bets include two over/under plays [9/12/2025]

Today’s free MLB picks for September 12, 2025 are here, with Friday’s MLB best bets fueled by thousands of data simulations analyzing the latest odds and matchups.

These MLB best bets include matchups like Angels vs. Mariners and Dodgers vs. Giants, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Friday, September 12, 2025, including our complete set of picks and best bets for today and the week ahead.

List of MLB best bets tonight [9/12, updated 10:03PM ET]

After crunching the numbers and running thousands of simulations, our independent predictive analytics model has identified the best baseball bets for Friday, September 12, 2025.

Angels vs. Mariners over 7.5 runs (-102)

• Probability: 53.9%
• Edge: 3.4%
• Matchup: Angels vs. Mariners (10:10PM ET, Friday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Angels vs. Mariners matchup. We recommend an over/under bet on over 7.5 runs at -102 odds, with our analysis showing a 53.9% chance of hitting and a compelling edge of 3.4%.

Dodgers vs. Giants over 7.5 runs (-105)

• Probability: 53.6%
• Edge: 2.4%
• Matchup: Dodgers vs. Giants (10:15PM ET, Friday)

Our model has found another strong MLB bet for Friday's baseball action, this time in the game between the Dodgers and Giants. We suggest placing an over/under wager on over 7.5 runs at -105 odds, with a 53.6% probability delivering a 2.4% edge.

MLB best bets: Friday, 9/12/2025

As of 10:03PM ET, here are our top two MLB bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Angels vs. Mariners	Over 7.5 Runs	-102 @ BetMGM	53.9%	3.4%
Dodgers vs. Giants	Over 7.5 Runs	-105 @ BetMGM	53.6%	2.4%

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's MLB picks is a -102 over/under bet with a 3.6% edge—the kind of high-upside play that makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 12, 2025.

List of upcoming MLB games to bet on [9/12/2025]

• Reds vs. Athletics (10:05PM ET, Friday)
• Angels vs. Mariners (10:10PM ET, Friday)
• Dodgers vs. Giants (10:15PM ET, Friday)
• Rays vs. Cubs (2:20PM ET, Saturday)
• Orioles vs. Blue Jays (3:07PM ET, Saturday)
• Pirates vs. Nationals (4:05PM ET, Saturday)
• Tigers vs. Marlins (4:10PM ET, Saturday)
• Yankees vs. Red Sox (4:10PM ET, Saturday)
• Rangers vs. Mets (4:10PM ET, Saturday)
• Royals vs. Phillies (6:05PM ET, Saturday)
• White Sox vs. Guardians (6:10PM ET, Saturday)
• D-Backs vs. Twins (7:10PM ET, Saturday)
• Astros vs. Braves (7:15PM ET, Saturday)
• Cardinals vs. Brewers (8:15PM ET, Saturday)
• Dodgers vs. Giants (9:05PM ET, Saturday)
• Angels vs. Mariners (9:40PM ET, Saturday)

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More about MLB

The bets on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for September 12, 2025, featuring plays such as over 7.5 runs in the Angels vs. Mariners matchup and over 7.5 runs in the Dodgers vs. Giants matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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