Free MLB picks today: Friday's MLB best bets include Athletics vs. Mariners play [8/22/2025]

Today’s free MLB picks for August 22, 2025 are here, with Friday’s MLB best bets backed by tens of thousands of data simulations analyzing the latest odds and matchups.

These MLB best bets include matchups like the Athletics vs. Mariners game at 10:10PM ET, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge MLB bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Friday, August 22, 2025, including our complete suite of picks and best bets for today and the week ahead.

List of MLB best bets tonight [8/22, updated 9:33PM ET]

After digging deep into the numbers and running thousands of simulations, our leading predictive analytics model has figured out the best baseball bet for Friday, August 22, 2025.

Athletics +1.5 (-111)

• Probability: 54.7%
• Edge: 2.0%
• matchup: Athletics vs. Mariners (10:10PM ET, Friday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Athletics vs. Mariners matchup. We recommend a run line bet on Athletics +1.5 at -111 odds, with our analysis showing a 54.7% chance of hitting and a compelling edge of 2.0%.

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for August 22, 2025.

List of Upcoming MLB Games to Bet On [8/22/2025]

• Cubs vs. Angels (9:38PM ET, Friday)
• Reds vs. D-Backs (9:40PM ET, Friday)
• Dodgers vs. Padres (9:40PM ET, Friday)
• Athletics vs. Mariners (10:10PM ET, Friday)
• Red Sox vs. Yankees (1:05PM ET, Saturday)
• Blue Jays vs. Marlins (4:10PM ET, Saturday)
• Nationals vs. Phillies (6:05PM ET, Saturday)
• Royals vs. Tigers (6:10PM ET, Saturday)
• Rockies vs. Pirates (6:40PM ET, Saturday)
• Astros vs. Orioles (7:05PM ET, Saturday)
• Guardians vs. Rangers (7:05PM ET, Saturday)
• Giants vs. Brewers (7:10PM ET, Saturday)
• Mets vs. Braves (7:15PM ET, Saturday)
• Reds vs. D-Backs (8:10PM ET, Saturday)
• Dodgers vs. Padres (8:40PM ET, Saturday)

More about MLB

The best on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for August 22, 2025, featuring plays such as Athletics +1.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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