Missouri State vs. Southern California prediction: Southern California favored to win in college football Week 1, 2025

Southern California will face Missouri State in college football action at Los Angeles Memorial Coliseum on Saturday, starting at 7:30PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts Southern California as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Missouri State vs. Southern California predictions page.

Missouri State vs. Southern California prediction: Who will win, cover the spread?

Using powerful machine learning and data analysis, we have simulated the result of Missouri State vs. Southern California 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Southern California a 98% chance of defeating Missouri State. Our predicted final score has Southern California winning 47-11.

According to our model, the bookmakers have got it right, and Missouri State and Southern California each have a 50% chance of covering the spread, while the over/under total of 60.5 points has a 53% chance of staying under.

Missouri State vs. Southern California odds

We have sourced the best College Football odds in America for this game, which are listed here:

Bet Type	Missouri State	Southern California
Spread	+36.5 (-108)	-36.5 (-105)
Moneyline	+5500	-9001
Total	o60.5 (-108)	u60.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Missouri State vs. Southern California picks and best bets

Our model's strongest edge in today's Missouri State vs. Southern California matchup is on the spread.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Missouri State vs. Southern California game-day updates and essential details

Saturday's college football game between Southern California and Missouri State at Los Angeles Memorial Coliseum is scheduled to commence at 7:30PM ET.

• Who: Missouri State vs. Southern California
• Date: Saturday, August 30, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Los Angeles Memorial Coliseum

Dimers.com's in-depth preview of Saturday's Missouri State vs. Southern California matchup includes our prediction, picks and the latest betting odds.

Before making any Missouri State vs. Southern California picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Southern California, with a 98% win probability, will likely beat Missouri State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Missouri State vs. Southern California insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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