Ole Miss vs. Kentucky prediction: Mississippi favored to win in college football Week 2, 2025

Kentucky and Mississippi will meet in Week 2 college football action at Kroger Field on Saturday, commencing at 3:30PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts Mississippi as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Ole Miss vs. Kentucky predictions page.

Ole Miss vs. Kentucky prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Ole Miss vs. Kentucky 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Mississippi a 71% chance of beating Kentucky. Our predicted final score has Mississippi winning 30-21.

According to our model, Mississippi (-7.5) has a 51% chance of covering the spread, while the over/under total of 50.5 points has a 54% chance of staying under.

Ole Miss vs. Kentucky odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Ole Miss	Kentucky
Spread	-7.5 (-102)	+7.5 (-110)
Moneyline	-290	+260
Total	o50.5 (-115)	u50.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Ole Miss vs. Kentucky picks and best bets

Our model's strongest edge in today's Ole Miss vs. Kentucky matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Ole Miss vs. Kentucky game-day updates and essential details

Saturday's college football matchup between Kentucky and Ole Miss at Kroger Field is scheduled to begin at 3:30PM ET.

• Who: Mississippi vs. Kentucky
• Date: Saturday, September 6, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Kroger Field

Dimers.com's comprehensive preview of Saturday's Ole Miss vs. Kentucky matchup includes our prediction, picks and the latest betting odds.

Before making any Ole Miss vs. Kentucky picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Mississippi, with a 71% win probability, will likely beat Kentucky on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Mississippi vs. Kentucky insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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