Mississippi State vs. Southern Miss prediction: Mississippi State favored to win in college football Week 1, 2025

Southern Miss will take on the favored Mississippi State in college football action at M.M. Roberts Stadium on Saturday, beginning at 12:00PM ET.

Based on updated simulation results, Dimers' advanced college football model projects Mississippi State as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Mississippi State vs. Southern Miss predictions page.

Mississippi State vs. Southern Miss prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of Mississippi State vs. Southern Miss 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Mississippi State an 80% chance of defeating Southern Miss. Our predicted final score has Mississippi State winning 37-22.

According to our model, the bookmakers have got it right, and Mississippi State and Southern Miss each have a 50% chance of covering the spread, while the over/under total of 59.5 points has a 53% chance of going over.

Mississippi State vs. Southern Miss odds

We have researched the best College Football odds in America for this game, which are listed here:

Bet Type	Mississippi State	Southern Miss
Spread	-14.5 (-105)	+14.5 (-114)
Moneyline	-600	+440
Total	o59.5 (-118)	u59.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Mississippi State vs. Southern Miss picks and best bets

Our model's strongest edge in today's Mississippi State vs. Southern Miss matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Mississippi State vs. Southern Miss game-day updates and essential details

Saturday's college football game between Southern Miss and Mississippi State at M.M. Roberts Stadium is scheduled to start at 12:00PM ET.

• Who: Mississippi State vs. Southern Miss
• Date: Saturday, August 30, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: M.M. Roberts Stadium

Dimers.com's in-depth preview of Saturday's Mississippi State vs. Southern Miss matchup includes our prediction, picks and the latest betting odds.

Before making any Mississippi State vs. Southern Miss picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Mississippi State, with an 80% win probability, will likely beat Southern Miss on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Mississippi State vs. Southern Miss insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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