Twins vs. Phillies prediction: Why Philadelphia is favored to win Friday's MLB matchup [9/26/2025]

The Philadelphia Phillies will take on the Minnesota Twins in MLB action at Citizens Bank Park on Friday, starting at 6:45PM ET.

Aaron Nola (4-10, 6.46 ERA) will start on the mound for the Phillies, while the Twins will counter with Joe Ryan (13-9, 3.47 ERA).

Based on updated simulation results, Dimers' proven MLB model projects the Phillies as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Twins vs. Phillies predictions page.

Phillies vs. Twins prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Friday's MLB matchup between the Twins and Phillies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Phillies a 58% chance of defeating the Twins.

According to our model, the Twins (+1.5) have a 60% chance of covering the run line, while the over/under total of 8.5 runs has a 56% chance of going over.

Twins vs. Phillies odds [9/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Twins	Phillies
Run Line	+1.5 (-169)	-1.5 (+142)
Moneyline	+130	-146
Total	o8.5 (-102)	u8.5 (-113)

All odds are correct at the time of publication and are subject to change.

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Twins vs. Phillies picks and best bets

Our model's biggest edge in today's Twins vs. Phillies matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

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Twins vs. Phillies game-day updates and essential details

Friday's MLB matchup between the Phillies and Twins at Citizens Bank Park is scheduled to begin at 6:45PM ET.

• Who: Minnesota Twins vs. Philadelphia Phillies
• Date: Friday, September 26, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Citizens Bank Park

Dimers' full preview of Friday's Twins vs. Phillies matchup includes our prediction, picks and the latest betting odds.

Before making any Twins vs. Phillies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Phillies, with a 58% win probability, will likely beat the Twins on Friday.

AI and automation have enhanced this article to quickly deliver accurate Twins vs. Phillies insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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