Twins vs. Tigers Prediction: Detroit Predicted to Win Wednesday's MLB Matchup [8/6/2025]

The Detroit Tigers and Minnesota Twins will meet in MLB action at Comerica Park on Wednesday, starting at 1:10PM ET.

The Tigers will start Jack Flaherty (6-10, 4.36 ERA), while the Twins will counter with Pierson Ohl (0-2, 7.50 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Tigers as the most likely winner of today's game. "Our team has simulated the outcome of Wednesday's Twins-Tigers game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Tigers' chance of winning at 64%, with the Twins at 36%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Twins vs. Tigers predictions page.

Tigers vs. Twins Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB game between the Twins and Tigers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Tigers a 64% chance of beating the Twins.

According to our model, the Twins (+1.5) have a 54% chance of covering the run line, while the over/under total of 9 runs has a 54% chance of staying under.

Twins vs. Tigers Odds [8/6/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Twins	Tigers
Run Line	+1.5 (-122)	-1.5 (+102)
Moneyline	+172	-200
Total	o9 (-107)	u9 (-110)

All odds are correct at the time of publication and are subject to change.

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Twins vs. Tigers Picks and Best Bets

Our model's biggest edge in today's Twins vs. Tigers matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Twins vs. Tigers Game-Day Updates and Essential Details

Wednesday's MLB game between the Tigers and Twins at Comerica Park is scheduled to start at 1:10PM ET.

• Who: Minnesota Twins vs. Detroit Tigers
• Date: Wednesday, August 6, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Comerica Park

Dimers.com's in-depth preview of Wednesday's Twins vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any Twins vs. Tigers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 64% win probability, will likely beat the Twins on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Twins vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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