Twins vs. Guardians Prediction: Minnesota Predicted to Win Wednesday's MLB Matchup [4/30/2025]

The Cleveland Guardians and Minnesota Twins will meet in MLB action at Progressive Field on Wednesday, starting at 6:10PM ET.

The Guardians will start Luis L. Ortiz (2-3, 5.96 ERA), while the Twins will counter with Pablo López (2-1, 2.08 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Twins as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Minnesota-Cleveland game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Twins' chance of winning at 52%, with the Guardians at 48%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Twins vs. Guardians predictions page.

Guardians vs. Twins Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB game between the Twins and Guardians 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Twins a 52% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 63% chance of covering the run line, while the 7-run over/under has a 54% chance of going over.

Twins vs. Guardians Odds [4/30/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Twins	Guardians
Run Line	-1.5 (+160)	+1.5 (-184)
Moneyline	-110	-104
Total	o7 (-115)	u7 (-102)

All odds are correct at the time of publication and are subject to change.

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Twins vs. Guardians Picks and Best Bets

Our model's strongest edge in today's Twins vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Twins vs. Guardians Game-Day Updates and Essential Details

Wednesday's MLB action between the Guardians and Twins at Progressive Field is scheduled to begin at 6:10PM ET.

• Who: Minnesota Twins vs. Cleveland Guardians
• Date: Wednesday, April 30, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Progressive Field

Dimers.com's comprehensive preview of Wednesday's Twins vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Minnesota vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Twins, with a 52% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Twins vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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