Twins vs. Guardians Prediction: Cleveland Predicted to Win Thursday's MLB Matchup [5/1/2025]

The Cleveland Guardians and Minnesota Twins are scheduled to meet in MLB action at Progressive Field on Thursday, starting at 1:10PM ET.

The Guardians will send Ben Lively (1-2, 4.40 ERA) to the mound, pitting him against Simeon Woods Richardson (2-2, 4.07 ERA) for the Twins.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Guardians as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Minnesota-Cleveland game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Guardians with a win probability of 52% and the Twins with 48%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Twins vs. Guardians predictions page.

Guardians vs. Twins Prediction: Who Will Win?

Using innovative machine learning and data, we have simulated the result of Thursday's MLB matchup between the Twins and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Guardians a 52% chance of defeating the Twins.

According to our model, the 9-run over/under also has an equal 50-50 chance of hitting.

Twins vs. Guardians Odds [5/1/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Twins	Guardians
Moneyline	-125	+110
Total	o9 (-118)	u9 (-102)

All odds are correct at the time of publication and are subject to change.

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Twins vs. Guardians Picks and Best Bets

Our model's biggest edge in today's Twins vs. Guardians matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Twins vs. Guardians Game-Day Updates and Essential Details

Thursday's MLB game between the Guardians and Twins at Progressive Field is scheduled to start at 1:10PM ET.

• Who: Minnesota Twins vs. Cleveland Guardians
• Date: Thursday, May 1, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Progressive Field

Dimers.com's in-depth preview of Thursday's Twins vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Minnesota vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 52% win probability, will likely beat the Twins on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Twins vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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