Twins vs. Guardians Prediction: Cleveland Predicted to Win Sunday's MLB Matchup [8/3/2025]

The Cleveland Guardians will face the Minnesota Twins in MLB action at Progressive Field on Sunday, commencing at 1:40PM ET.

Joey Cantillo (2-1, 4.14 ERA) will get the ball for the Guardians, while the Twins are going with José Ureña (0-0, 5.40 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game. "Using the most recent data, our experts ran 10,000 simulations of Sunday's Twins-Guardians game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Guardians with a win probability of 62%, while the Twins have 38%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Twins vs. Guardians predictions page.

Guardians vs. Twins Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Sunday's MLB game between the Twins and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Guardians a 62% chance of defeating the Twins.

According to our model, the Twins (+1.5) have a 56% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of staying under.

Twins vs. Guardians Odds [8/3/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Twins	Guardians
Run Line	+1.5 (-154)	-1.5 (+129)
Moneyline	+142	-168
Total	o8.5 (-102)	u8.5 (-118)

All odds are correct at the time of publication and are subject to change.

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Twins vs. Guardians Picks and Best Bets

Our model's strongest edge in today's Twins vs. Guardians matchup is on the total.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Twins vs. Guardians Game-Day Updates and Essential Details

Sunday's MLB game between the Guardians and Twins at Progressive Field is scheduled to start at 1:40PM ET.

• Who: Minnesota Twins vs. Cleveland Guardians
• Date: Sunday, August 3, 2025
• Time: 1:40PM ET/10:40AM PT
• Venue: Progressive Field

Dimers.com's in-depth preview of Sunday's Twins vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Twins vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Guardians, with a 62% win probability, will likely beat the Twins on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Twins vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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