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Twins vs. Guardians Prediction: Cleveland Predicted to Win Friday's MLB Matchup [8/1/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Our expert prediction for Friday's Minnesota Twins vs Cleveland Guardians matchup.
The Cleveland Guardians will square off with the Minnesota Twins in MLB action at Progressive Field on Friday, beginning at 7:10PM ET.
The Guardians will start Gavin Williams (6-4, 3.51 ERA), up against Joe Ryan (10-5, 2.82 ERA) for the Twins.
Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.
For a closer look at Friday's matchup, including best bets and picks, visit our interactive Twins vs. Guardians predictions page.
Guardians vs. Twins Prediction: Who Will Win, Cover the Run Line?
Using trusted machine learning and statistical analysis, we have simulated the result of Friday's MLB game between the Twins and Guardians 10,000 times as part of our MLB predictions coverage.
Our independent predictive model currently gives the Guardians a 55% chance of defeating the Twins.
According to our model, the Twins (+1.5) have a 64% chance of covering the run line, while the 7-run over/under has a 53% chance of going over.
Twins vs. Guardians Odds [8/1/2025]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Twins | Guardians |
|---|---|---|
| Run Line | +1.5 (-210) | -1.5 (+173) |
| Moneyline | +105 | -121 |
| Total | o7 (-104) | u7 (-115) |
All odds are correct at the time of publication and are subject to change.
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Twins vs. Guardians Picks and Best Bets
Our model's strongest edge in today's Twins vs. Guardians matchup is on the run line.
Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Free MLB Picks
Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.
Twins vs. Guardians Game-Day Updates and Essential Details
Friday's MLB action between the Guardians and Twins at Progressive Field is scheduled to begin at 7:10PM ET.
- Who: Minnesota Twins vs. Cleveland Guardians
- Date: Friday, August 1, 2025
- Time: 7:10PM ET/4:10PM PT
- Venue: Progressive Field
Dimers.com's comprehensive preview of Friday's Twins vs. Guardians matchup includes our prediction, picks and the latest betting odds.
Before making any Twins vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Conclusion
We predict the Guardians, with a 55% win probability, will likely beat the Twins on Friday.
AI and automation have enhanced this article to quickly deliver accurate Twins vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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