Twins vs. White Sox prediction: Why Minnesota is favored to win Friday's MLB matchup [8/22/2025]

The Chicago White Sox will square off with the Minnesota Twins in MLB action at Rate Field on Friday, commencing at 7:40PM ET.

Aaron Civale (3-8, 4.88 ERA) will be the starting pitcher for the White Sox, while the Twins have opted for Zebby Matthews (3-4, 5.06 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Twins as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Twins vs. White Sox predictions page.

White Sox vs. Twins prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Friday's MLB game between the Twins and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Twins a 55% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 58% chance of covering the run line, while the 8.5-run over/under has a 52% chance of going over.

Twins vs. White Sox odds [8/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Twins	White Sox
Run Line	-1.5 (+135)	+1.5 (-154)
Moneyline	-130	+110
Total	o8.5 (-102)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Twins vs. White Sox picks and best bets

Our model's biggest edge in today's Twins vs. White Sox matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Twins vs. White Sox game-day updates and essential details

Friday's MLB game between the White Sox and Twins at Rate Field is scheduled to start at 7:40PM ET.

• Who: Minnesota Twins vs. Chicago White Sox
• Date: Friday, August 22, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers.com's comprehensive preview of Friday's Twins vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Twins vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Sports betting deal available for Friday

To make the most of Friday's mammoth day of sports, headlined by the TOUR Championship golf tournament and a huge day of MLB, check out details on the latest Bet365 bonus that scores you $200 in bonus bets from a $5 bet. Don't miss out!

Conclusion

We predict the Twins, with a 55% win probability, will likely beat the White Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate Twins vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest projections for the World Series, American League, National League and each division.