Brewers vs. Cardinals prediction: Milwaukee favored to win Sunday's MLB matchup [9/21/2025]

The St. Louis Cardinals will face the Milwaukee Brewers, in what is expected to be a tight MLB game, at Busch Stadium on Sunday, commencing at 2:15PM ET.

The Cardinals will have Matthew Liberatore (7-12, 4.30 ERA) as their starting pitcher, while the Brewers will counter with Robert Gasser (0-0, 0.00 ERA).

Based on updated simulations, Dimers' advanced MLB model predicts the Brewers as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Brewers-Cardinals game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Brewers with a win probability of 53%, while the Cardinals have 47%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Brewers vs. Cardinals predictions page.

Cardinals vs. Brewers prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Sunday's MLB game between the Brewers and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Brewers a 53% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of going over.

Brewers vs. Cardinals odds [9/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Cardinals
Run Line	-1.5 (+125)	+1.5 (-149)
Moneyline	-130	+113
Total	o8.5 (-105)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Cardinals picks and best bets

Our model's strongest edge in today's Brewers vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Brewers vs. Cardinals game-day updates and essential details

Sunday's MLB action between the Cardinals and Brewers at Busch Stadium is scheduled to begin at 2:15PM ET.

• Who: Milwaukee Brewers vs. St. Louis Cardinals
• Date: Sunday, September 21, 2025
• Time: 2:15PM ET/11:15AM PT
• Venue: Busch Stadium

Dimers' full preview of Sunday's Brewers vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Brewers, with a 53% win probability, will likely beat the Cardinals on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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