Brewers vs. Cardinals prediction: Milwaukee favored to win Saturday's MLB matchup [9/20/2025]

The St. Louis Cardinals will take on the Milwaukee Brewers, in what is expected to be a tight MLB game, at Busch Stadium on Saturday, commencing at 7:15PM ET.

Miles Mikolas (8-10, 4.80 ERA) will get the ball for the Cardinals, pitting him against Chad Patrick (3-8, 3.64 ERA) for the Brewers.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Brewers as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Brewers vs. Cardinals predictions page.

Cardinals vs. Brewers prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Saturday's MLB matchup between the Brewers and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Brewers a 54% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 58% chance of covering the run line, while the 8.5-run over/under has a 56% chance of going over.

Brewers vs. Cardinals odds [9/20/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Cardinals
Run Line	-1.5 (+115)	+1.5 (-134)
Moneyline	-140	+122
Total	o8.5 (-115)	u8.5 (-101)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Cardinals picks and best bets

Our model's biggest edge in today's Brewers vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Brewers vs. Cardinals game-day updates and essential details

Saturday's MLB game between the Cardinals and Brewers at Busch Stadium is scheduled to commence at 7:15PM ET.

• Who: Milwaukee Brewers vs. St. Louis Cardinals
• Date: Saturday, September 20, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Busch Stadium

Dimers' full preview of Saturday's Brewers vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Brewers, with a 54% win probability, will likely beat the Cardinals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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