Brewers vs. Cardinals prediction: Milwaukee favored to win Friday's MLB matchup [9/19/2025]

The St. Louis Cardinals and Milwaukee Brewers will meet in MLB action at Busch Stadium on Friday, starting at 8:15PM ET.

The Cardinals will start Sonny Gray (13-8, 4.43 ERA), while the Brewers have opted for Jacob Misiorowski (5-2, 4.35 ERA).

Based on the latest simulations, Dimers' advanced MLB model projects the Brewers as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Brewers vs. Cardinals predictions page.

Cardinals vs. Brewers prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB matchup between the Brewers and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Brewers a 51% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 63% chance of covering the run line, while the over/under total of 7.5 runs has a 54% chance of going over.

Brewers vs. Cardinals odds [9/19/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Cardinals
Run Line	-1.5 (+140)	+1.5 (-164)
Moneyline	-118	+105
Total	o7.5 (-105)	u7.5 (-108)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Brewers vs. Cardinals picks and best bets

Our model's strongest edge in today's Brewers vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Brewers vs. Cardinals game-day updates and essential details

Friday's MLB game between the Cardinals and Brewers at Busch Stadium is scheduled to start at 8:15PM ET.

• Who: Milwaukee Brewers vs. St. Louis Cardinals
• Date: Friday, September 19, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Busch Stadium

Dimers' comprehensive preview of Friday's Brewers vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with sports betting in Missouri set to launch on December 1, 2025, Dimers has everything you need—from the latest updates and the best MO sports betting promos.

Conclusion

We predict the Brewers, with a 51% win probability, will likely beat the Cardinals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest projections for the World Series, American League, National League and each division.