Brewers vs. Cardinals Prediction: St. Louis Predicted to Win Friday's MLB Matchup [4/25/2025]

The St. Louis Cardinals and Milwaukee Brewers will lock horns in MLB action at Busch Stadium on Friday, starting at 8:15PM ET.

The Cardinals will start Matthew Liberatore (1-2, 3.60 ERA), while the Brewers have opted for Chad Patrick (1-1, 2.11 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Milwaukee-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Cardinals' chance of winning is 56%, while the Brewers' is 44%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Brewers vs. Cardinals predictions page.

Cardinals vs. Brewers Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Friday's MLB matchup between the Brewers and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cardinals a 56% chance of beating the Brewers.

According to our model, the Brewers (+1.5) have a 63% chance of covering the run line, while the 8-run over/under has a 51% chance of staying under.

Brewers vs. Cardinals Odds [4/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Cardinals
Run Line	+1.5 (-188)	-1.5 (+160)
Moneyline	+115	-130
Total	o8 (-104)	u8 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Brewers vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Brewers vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Brewers vs. Cardinals Game-Day Updates and Essential Details

Friday's MLB game between the Cardinals and Brewers at Busch Stadium is scheduled to start at 8:15PM ET.

• Who: Milwaukee Brewers vs. St. Louis Cardinals
• Date: Friday, April 25, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Friday's Brewers vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Milwaukee vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Cardinals, with a 56% win probability, will likely beat the Brewers on Friday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest predictions for the World Series, American League, National League and each division.