Brewers vs. Padres prediction: San Diego favored to win Tuesday's MLB matchup [9/23/2025]

The San Diego Padres will face the Milwaukee Brewers, in what is expected to be a tight MLB game, at PETCO Park on Tuesday, starting at 9:40PM ET.

Randy Vásquez (5-7, 3.94 ERA) will get the ball for the Padres, pitting him against Bruce Zimmermann (0-0, 0.00 ERA) for the Brewers.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Padres as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Brewers vs. Padres predictions page.

Padres vs. Brewers prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Tuesday's MLB matchup between the Brewers and Padres 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Padres a 51% chance of beating the Brewers.

According to our model, the Padres (+1.5) have a 63% chance of covering the run line, while the 8-run over/under has a 59% chance of going over.

Brewers vs. Padres odds [9/23/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Padres
Run Line	-1.5 (+134)	+1.5 (-155)
Moneyline	-120	+110
Total	o8 (-110)	u8 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Brewers vs. Padres picks and best bets

Our model's strongest edge in today's Brewers vs. Padres matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Brewers vs. Padres game-day updates and essential details

Tuesday's MLB game between the Padres and Brewers at PETCO Park is scheduled to start at 9:40PM ET.

• Who: Milwaukee Brewers vs. San Diego Padres
• Date: Tuesday, September 23, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers' in-depth preview of Tuesday's Brewers vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 51% win probability, will likely beat the Brewers on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest projections for the World Series, American League, National League and each division.