Brewers vs. Padres prediction: Cy Young candidate Freddy Peralta takes on San Diego tonight [9/22/2025]

The San Diego Padres will square off with the Milwaukee Brewers in MLB action at PETCO Park on Monday, beginning at 9:40PM ET.

The Padres will send Nick Pivetta (13-5, 2.81 ERA) to the mound, while the Brewers will counter with Cy Young hopeful Freddy Peralta (17-6, 2.65 ERA).

Based on updated simulation results, Dimers' proven MLB model predicts the Padres as the most likely winner of today's game.

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Brewers vs. Padres predictions page.

Padres vs. Brewers prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Monday's MLB game between the Brewers and Padres 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Padres a 54% chance of defeating the Brewers.

According to our model, the Padres (+1.5) have a 68% chance of covering the run line, while the 7-run over/under has a 57% chance of going over.

Brewers vs. Padres odds [9/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Padres
Run Line	-1.5 (+165)	+1.5 (-192)
Moneyline	-110	-105
Total	o7 (-102)	u7 (-115)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Padres picks and best bets

Our model's strongest edge in today's Brewers vs. Padres matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Brewers vs. Padres game-day updates and essential details

Monday's MLB game between the Padres and Brewers at PETCO Park is scheduled to start at 9:40PM ET.

• Who: Milwaukee Brewers vs. San Diego Padres
• Date: Monday, September 22, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers' in-depth preview of Monday's Brewers vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 54% win probability, will likely beat the Brewers on Monday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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