Brewers vs. Pirates Prediction: Pittsburgh Predicted to Win Thursday's MLB Matchup [5/22/2025]

The Pittsburgh Pirates and Milwaukee Brewers are scheduled to meet in MLB action at PNC Park on Thursday, starting at 6:40PM ET.

The Pirates will start Mike Burrows (0-0, 0.00 ERA), while the Brewers have opted for Aaron Civale (0-1, 15.00 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Pirates as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Milwaukee-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Pirates with a win probability of 51% and the Brewers with 49%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Brewers vs. Pirates predictions page.

Pirates vs. Brewers Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Thursday's MLB matchup between the Brewers and Pirates 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Pirates a 51% chance of defeating the Brewers.

According to our model, the Pirates (+1.5) have a 63% chance of covering the run line, while the over/under total of 9 runs has a 56% chance of staying under.

Brewers vs. Pirates Odds [5/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Pirates
Run Line	-1.5 (+140)	+1.5 (-154)
Moneyline	-115	-102
Total	o9 (+102)	u9 (-120)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Brewers vs. Pirates matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Brewers vs. Pirates Game-Day Updates and Essential Details

Thursday's MLB matchup between the Pirates and Brewers at PNC Park is scheduled to begin at 6:40PM ET.

• Who: Milwaukee Brewers vs. Pittsburgh Pirates
• Date: Thursday, May 22, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's comprehensive preview of Thursday's Brewers vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Milwaukee vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Pirates, with a 51% win probability, will likely beat the Brewers on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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