Brewers vs. Pirates prediction: Why Milwaukee is favored to win Saturday's MLB matchup [9/6/2025]

The Pittsburgh Pirates will take on the Milwaukee Brewers in MLB action at PNC Park on Saturday, starting at 6:40PM ET.

Mitch Keller (6-13, 4.21 ERA) will get the ball for the Pirates, while the Brewers will counter with Brandon Woodruff (5-2, 3.69 ERA).

Based on updated simulation results, Dimers' advanced MLB model projects the Brewers as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Brewers vs. Pirates predictions page.

Pirates vs. Brewers prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Saturday's MLB matchup between the Brewers and Pirates 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Brewers a 56% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 58% chance of covering the run line, while the 7.5-run over/under has a 54% chance of going over.

Brewers vs. Pirates odds [9/6/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Pirates
Run Line	-1.5 (+115)	+1.5 (-134)
Moneyline	-144	+122
Total	o7.5 (-108)	u7.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Pirates picks and best bets

Our model's strongest edge in today's Brewers vs. Pirates matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Brewers vs. Pirates game-day updates and essential details

Saturday's MLB matchup between the Pirates and Brewers at PNC Park is scheduled to start at 6:40PM ET.

• Who: Milwaukee Brewers vs. Pittsburgh Pirates
• Date: Saturday, September 6, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's in-depth preview of Saturday's Brewers vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Pirates picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Brewers, with a 56% win probability, will likely beat the Pirates on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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