Brewers vs. Pirates Prediction: Pittsburgh Predicted to Win Friday's MLB Matchup [5/23/2025]

MLB action continues on Friday at 6:40PM ET as the Milwaukee Brewers lock horns with the Pittsburgh Pirates at PNC Park.

The Pirates will start Paul Skenes (3-5, 2.44 ERA), while the Brewers have opted for Freddy Peralta (5-3, 2.59 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Pirates as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Milwaukee-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Pirates' chance of winning is 55%, while the Brewers' is 45%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Brewers vs. Pirates predictions page.

Pirates vs. Brewers Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Friday's MLB matchup between the Brewers and Pirates 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Pirates a 55% chance of beating the Brewers.

According to our model, the Brewers (+1.5) have a 65% chance of covering the run line, while the over/under total of 7 runs has a 51% chance of staying under.

Brewers vs. Pirates Odds [5/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Pirates
Run Line	+1.5 (-220)	-1.5 (+180)
Moneyline	+110	-124
Total	o7 (-110)	u7 (-110)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Pirates Picks and Best Bets

Our model's strongest edge in today's Brewers vs. Pirates matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Brewers vs. Pirates Game-Day Updates and Essential Details

Friday's MLB action between the Pirates and Brewers at PNC Park is scheduled to begin at 6:40PM ET.

• Who: Milwaukee Brewers vs. Pittsburgh Pirates
• Date: Friday, May 23, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's full preview of Friday's Brewers vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Milwaukee vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Pirates, with a 55% win probability, will likely beat the Brewers on Friday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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