Brewers vs. Pirates prediction: Why Milwaukee is favored to win Friday's MLB matchup [9/5/2025]

The Pittsburgh Pirates will square off with the Milwaukee Brewers in MLB action at PNC Park on Friday, commencing at 6:40PM ET.

The Pirates will have Johan Oviedo (2-0, 3.60 ERA) as their starting pitcher, while the Brewers are going with Quinn Priester (11-2, 3.28 ERA).

Based on the latest simulations, Dimers' proven MLB model projects the Brewers as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Brewers vs. Pirates predictions page.

Pirates vs. Brewers prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Friday's MLB game between the Brewers and Pirates 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Brewers a 54% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 60% chance of covering the run line, while the over/under total of 8.5 runs has an equal 50-50 chance of hitting.

Brewers vs. Pirates odds [9/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Pirates
Run Line	-1.5 (+125)	+1.5 (-146)
Moneyline	-135	+118
Total	o8.5 (-103)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Pirates picks and best bets

Our model's biggest edge in today's Brewers vs. Pirates matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Brewers vs. Pirates game-day updates and essential details

Friday's MLB action between the Pirates and Brewers at PNC Park is scheduled to start at 6:40PM ET.

• Who: Milwaukee Brewers vs. Pittsburgh Pirates
• Date: Friday, September 5, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's full preview of Friday's Brewers vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Pirates picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Brewers, with a 54% win probability, will likely beat the Pirates on Friday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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