Brewers vs. Guardians Prediction: Cleveland Predicted to Win Wednesday's MLB Matchup [5/14/2025]

The Cleveland Guardians will face the Milwaukee Brewers in MLB action at Progressive Field on Wednesday, commencing at 1:10PM ET.

The Guardians will start Gavin Williams (3-2, 4.38 ERA), while the Brewers are going with Logan Henderson (1-0, 1.50 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Milwaukee-Cleveland game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Guardians' chance of winning at 54%, with the Brewers at 46%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Brewers vs. Guardians predictions page.

Guardians vs. Brewers Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB matchup between the Brewers and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Guardians a 54% chance of defeating the Brewers.

According to our model, the Brewers (+1.5) have a 64% chance of covering the run line, while the over/under total of 8.5 runs has a 54% chance of staying under.

Brewers vs. Guardians Odds [5/14/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Guardians
Run Line	+1.5 (-188)	-1.5 (+165)
Moneyline	+110	-120
Total	o8.5 (-102)	u8.5 (-118)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Brewers vs. Guardians Picks and Best Bets

Our model's strongest edge in today's Brewers vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Brewers vs. Guardians Game-Day Updates and Essential Details

Wednesday's MLB game between the Guardians and Brewers at Progressive Field is scheduled to begin at 1:10PM ET.

• Who: Milwaukee Brewers vs. Cleveland Guardians
• Date: Wednesday, May 14, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Progressive Field

Dimers.com's comprehensive preview of Wednesday's Brewers vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Milwaukee vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Guardians, with a 54% win probability, will likely beat the Brewers on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest probabilities for the World Series, American League, National League and each division.