Brewers vs. Reds prediction: Milwaukee predicted to win Saturday's MLB matchup [8/16/2025]

The Cincinnati Reds will square off with the Milwaukee Brewers in MLB action at Great American Ball Park on Saturday, beginning at 6:40PM ET.

Zack Littell (9-8, 3.60 ERA) will be the starting pitcher for the Reds, pitting him against Quinn Priester (11-2, 3.49 ERA) for the Brewers.

Based on the latest simulation results, Dimers' advanced MLB model projects the Brewers as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Brewers vs. Reds predictions page.

Reds vs. Brewers prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Saturday's MLB game between the Brewers and Reds 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Brewers a 54% chance of defeating the Reds.

According to our model, the Reds (+1.5) have a 60% chance of covering the run line, while the 8.5-run over/under has a 51% chance of going over.

Brewers vs. Reds odds [8/16/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Reds
Run Line	-1.5 (+138)	+1.5 (-158)
Moneyline	-120	+105
Total	o8.5 (-120)	u8.5 (+101)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Reds picks and best bets

Our model's strongest edge in today's Brewers vs. Reds matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

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Brewers vs. Reds game-day updates and essential details

Saturday's MLB action between the Reds and Brewers at Great American Ball Park is scheduled to start at 6:40PM ET.

• Who: Milwaukee Brewers vs. Cincinnati Reds
• Date: Saturday, August 16, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers.com's full preview of Saturday's Brewers vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Brewers, with a 54% win probability, will likely beat the Reds on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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