Brewers vs. Cubs prediction: Tight battle projected in updated analysis for Wednesday's MLB matchup [8/20/2025]

The Chicago Cubs will square off with the Milwaukee Brewers, in what is expected to be a tight MLB game, at Wrigley Field on Wednesday, commencing at 8:05PM ET.

The Cubs will start Colin Rea (9-5, 4.00 ERA), while the Brewers have opted for Jacob Misiorowski (4-1, 3.89 ERA).

Based on updated simulations, Dimers' proven MLB model predicts an equal chance for both the Cubs and Brewers to win today's game.

"Our team has simulated the outcome of Wednesday's Brewers-Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Cubs and Brewers, making it a highly competitive matchup."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Brewers vs. Cubs predictions page.

Cubs vs. Brewers prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB game between the Brewers and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently can't split the two teams, giving both the Brewers and Cubs a 50% chance of winning the game.

According to our model, the Cubs (+1.5) have a 64% chance of covering the run line, while the over/under total of 6.5 runs has a 56% chance of going over.

Brewers vs. Cubs odds [8/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Cubs
Run Line	-1.5 (+154)	+1.5 (-182)
Moneyline	-118	+100
Total	o6.5 (-118)	u6.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Cubs picks and best bets

Our model's biggest edge in today's Brewers vs. Cubs matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Brewers vs. Cubs game-day updates and essential details

Wednesday's MLB game between the Cubs and Brewers at Wrigley Field is scheduled to commence at 8:05PM ET.

• Who: Milwaukee Brewers vs. Chicago Cubs
• Date: Wednesday, August 20, 2025
• Time: 8:05PM ET/5:05PM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Wednesday's Brewers vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict a close game between the Brewers and Cubs on Wednesday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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