Brewers vs. Cubs prediction: Cubs favored to win Thursday's MLB matchup [8/21/2025]

The Chicago Cubs will take on the Milwaukee Brewers in MLB action at Wrigley Field on Thursday, beginning at 2:20PM ET.

The Cubs will have Shota Imanaga (8-5, 3.06 ERA) as their starting pitcher, pitting him against Quinn Priester (11-2, 3.48 ERA) for the Brewers.

Based on updated simulations, Dimers' advanced MLB model predicts the Cubs as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Brewers vs. Cubs predictions page.

Cubs vs. Brewers prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Thursday's MLB matchup between the Brewers and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cubs a 57% chance of beating the Brewers.

According to our model, the Brewers (+1.5) have a 63% chance of covering the run line, while the over/under total of 6.5 runs has a 56% chance of going over.

Brewers vs. Cubs odds [8/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Cubs
Run Line	+1.5 (-190)	-1.5 (+162)
Moneyline	+118	-138
Total	o6.5 (-115)	u6.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Cubs picks and best bets

Our model's biggest edge in today's Brewers vs. Cubs matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Brewers vs. Cubs game-day updates and essential details

Thursday's MLB action between the Cubs and Brewers at Wrigley Field is scheduled to begin at 2:20PM ET.

• Who: Milwaukee Brewers vs. Chicago Cubs
• Date: Thursday, August 21, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Thursday's Brewers vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 57% win probability, will likely beat the Brewers on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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