Michigan vs. Oklahoma prediction: Oklahoma favored to win in college football Week 2, 2025

Oklahoma will take on Michigan in Week 2 college football action at Gaylord Family Oklahoma Memorial Stadium on Saturday, beginning at 7:30PM ET.

Based on the latest simulation results, Dimers' proven college football model predicts Oklahoma as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Michigan vs. Oklahoma predictions page.

Michigan vs. Oklahoma prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the result of Michigan vs. Oklahoma 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Oklahoma a 58% chance of defeating Michigan. Our predicted final score has Oklahoma winning 24-21.

According to our model, Michigan (+8.5) has a 64% chance of covering the spread, while the over/under total of 47.5 points has a 63% chance of staying under.

Michigan vs. Oklahoma odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Michigan	Oklahoma
Spread	+8.5 (-115)	-8.5 (-114)
Moneyline	+260	-185
Total	o47.5 (-118)	u47.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Michigan vs. Oklahoma picks and best bets

Our model's strongest edge in today's Michigan vs. Oklahoma matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Michigan vs. Oklahoma game-day updates and essential details

Saturday's college football matchup between Oklahoma and Michigan at Gaylord Family Oklahoma Memorial Stadium is scheduled to begin at 7:30PM ET.

• Who: Michigan vs. Oklahoma
• Date: Saturday, September 6, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Gaylord Family Oklahoma Memorial Stadium

Dimers.com's full preview of Saturday's Michigan vs. Oklahoma matchup includes our prediction, picks and the latest betting odds.

Before making any Michigan vs. Oklahoma picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Oklahoma, with a 58% win probability, will likely beat Michigan on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Michigan vs. Oklahoma insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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