Michigan State vs. Southern California prediction: Southern California favored to win in college football Week 4, 2025

Southern California will take on Michigan State in Week 4 college football action at Los Angeles Memorial Coliseum on Saturday, commencing at 11:00PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts Southern California as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Michigan State vs. Southern California predictions page.

Michigan State vs. Southern California prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of Michigan State vs. Southern California 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Southern California an 87% chance of beating Michigan State. Our predicted final score has Southern California winning 38-19.

According to our model, Michigan State (+19.5) has a 52% chance of covering the spread, while the 55.5-point over/under has a 53% chance of staying under.

Michigan State vs. Southern California odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Michigan State	Southern California
Spread	+19.5 (-110)	-19.5 (-110)
Moneyline	+650	-1000
Total	o55.5 (-105)	u55.5 (-108)

All odds are correct at the time of publication and are subject to change.

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Michigan State vs. Southern California picks and best bets

Our model's biggest edge in today's Michigan State vs. Southern California matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Michigan State vs. Southern California game-day updates and essential details

Saturday's college football game between Southern California and Michigan State at Los Angeles Memorial Coliseum is scheduled to start at 11:00PM ET.

• Who: Michigan State vs. Southern California
• Date: Saturday, September 20, 2025
• Time: 11:00PM ET/8:00PM PT
• Venue: Los Angeles Memorial Coliseum

Dimers' in-depth preview of Saturday's Michigan State vs. Southern California matchup includes our prediction, picks and the latest betting odds.

Before making any Michigan State vs. Southern California picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Southern California, with an 87% win probability, will likely beat Michigan State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Michigan State vs. Southern California insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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