Marlins vs. Padres Prediction: San Diego Predicted to Win Wednesday's MLB Matchup [5/28/2025]

The San Diego Padres will square off with the Miami Marlins in MLB action at PETCO Park on Wednesday, beginning at 4:10PM ET.

The Padres will send Kyle Hart (2-2, 6.00 ERA) to the mound, pitting him against Sandy Alcantara (2-7, 8.04 ERA) for the Marlins.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Miami-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 61%, with the Marlins at 39%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Marlins vs. Padres predictions page.

Padres vs. Marlins Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Marlins and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 61% chance of beating the Marlins.

According to our model, the Marlins (+1.5) have a 59% chance of covering the run line, while the over/under total of 8.5 runs has an equal 50-50 chance of hitting.

Marlins vs. Padres Odds [5/28/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Marlins	Padres
Run Line	+1.5 (-160)	-1.5 (+136)
Moneyline	+136	-155
Total	o8.5 (-115)	u8.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Marlins vs. Padres Picks and Best Bets

Our model's strongest edge in today's Marlins vs. Padres matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Marlins vs. Padres Game-Day Updates and Essential Details

Wednesday's MLB action between the Padres and Marlins at PETCO Park is scheduled to commence at 4:10PM ET.

• Who: Miami Marlins vs. San Diego Padres
• Date: Wednesday, May 28, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Wednesday's Marlins vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Miami vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 61% win probability, will likely beat the Marlins on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Marlins vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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