Marlins vs. Padres Prediction: San Diego Predicted to Win Monday's MLB Matchup [5/26/2025]

The San Diego Padres will square off with the Miami Marlins in MLB action at PETCO Park on Monday, starting at 8:40PM ET.

Randy Vásquez (3-4, 3.49 ERA) will start on the mound for the Padres, up against Ryan Weathers (1-0, 1.80 ERA) for the Marlins.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Miami-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Padres are likely to win, with a probability of 58%, compared to the Marlins' 42%."

For further insights into Monday's matchup, including best bets and picks, visit our interactive Marlins vs. Padres predictions page.

Padres vs. Marlins Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Monday's MLB matchup between the Marlins and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Padres a 58% chance of beating the Marlins.

According to our model, the Marlins (+1.5) have a 61% chance of covering the run line, while the 8-run over/under has a 52% chance of staying under.

Marlins vs. Padres Odds [5/26/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Marlins	Padres
Run Line	+1.5 (-162)	-1.5 (+145)
Moneyline	+136	-150
Total	o8 (-102)	u8 (-118)

All odds are correct at the time of publication and are subject to change.

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Marlins vs. Padres Picks and Best Bets

Our model's strongest edge in today's Marlins vs. Padres matchup is on the total.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Marlins vs. Padres Game-Day Updates and Essential Details

Monday's MLB game between the Padres and Marlins at PETCO Park is scheduled to start at 8:40PM ET.

• Who: Miami Marlins vs. San Diego Padres
• Date: Monday, May 26, 2025
• Time: 8:40PM ET/5:40PM PT
• Venue: PETCO Park

Dimers.com's full preview of Monday's Marlins vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Miami vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Padres, with a 58% win probability, will likely beat the Marlins on Monday.

AI and automation have enhanced this article to quickly deliver accurate Marlins vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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